Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia.

International journal of molecular sciences - 15 Jun 2024

Mandell Jeffrey D, Diviti Saathvika, Xu Mina, Townsend Jeffrey P

Abstract excerpt

The genomic analyses of pediatric acute lymphoblastic leukemia (ALL) subtypes, particularly T-cell and B-cell lineages, have been pivotal in identifying potential therapeutic targets. Typical genomic analyses have directed attention toward the most commonly mutated genes. However, assessing the contribution of mutations to cancer phenotypes is crucial. Therefore, we estimated the cancer effects (scaled selection...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Child
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 38928295
DOI: 10.3390/ijms25126589
PMCID: PMC11203805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare Drivers at Low Prevalence with High Cancer Effects in T-Cell and B-Cell Pediatric Acute Lymphoblastic Leukemia.PMID 38928295Read ↗

Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia.Semantic proximity Read ↗

Unraveling the cellular origin and clinical prognostic markers of infant B-cell acute lymphoblastic leukemia using genome-wide analysisSemantic proximity Read ↗

The RAS-signaling-pathway-mutation-related prognosis in B-cell acute lymphoblastic leukemia: A report from South China children's leukemia group.Semantic proximity Read ↗

Overt and covert genetic causes of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Characteristics of Molecular Genetic Mutations and Their Correlation with Prognosis in Adolescent and Adult Patients with Acute Lymphoblastic Leukemia.Semantic proximity Read ↗

Spectrum and clinical characteristics relevance of gene mutations in Chinese pediatric acute lymphoblastic leukemiaSemantic proximity Read ↗

Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencingSemantic proximity Read ↗

Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancersSemantic proximity Read ↗

The landscape of structural variation in pediatric cancerSemantic proximity Read ↗

The genomic landscape of pediatric acute lymphoblastic leukemia.Semantic proximity Read ↗

Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.