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Article

IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities.

Cancer prevention research (Philadelphia, Pa.) - 1 Dec 2017

Lopes Bruno A, Barbosa Thayana C, Souza Bruna K S, Poubel Caroline P, Pombo-de-Oliveira Maria S, Emerenciano Mariana

Abstract excerpt

SNPs in IKZF1 are associated with inherited susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Besides, somatic copy number abnormalities (CNA) in genes related to lymphopoiesis (e.g., IKZF1, CDKN2A/B, BTG1) impact patient's outcome. Therefore, this study aimed to investigate an association between germline susceptibility and CNAs in BCP-ALL. The IKZF1 SNPs (rs11978267 and rs4132601) were...

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Share to Chromosome Aberrations
Share to Cyclin-Dependent Kinase Inhibitor p16
Share to Cyclin-Dependent Kinase Inhibitor p18
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Identifiers

PMID: 28947432
DOI: 10.1158/1940-6207.CAPR-17-0121

Genes

IKZF1
BTG1

Provenance

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IKZF1 Gene in Childhood B-cell Precursor Acute Lymphoblastic Leukemia: Interplay between Genetic Susceptibility and Somatic Abnormalities.PMID 28947432Read ↗

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Investigating the impact of IKZF1 SNPs rs4132601 and rs11978267 on acute lymphoblastic leukemia: a comprehensive meta-analysis.Semantic proximity Read ↗

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