Genetic Risk Factors for Kidney Function in Individuals with Type 1 Diabetes.

doi:10.2215/CJN.0000001111

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Article

Genetic Risk Factors for Kidney Function in Individuals with Type 1 Diabetes.

Clinical journal of the American Society of Nephrology : CJASN - 1 Sept 2026

Limonte Christine P, Gao Xiaoyu, Roshandel Delnaz, Bebu Ionut, Karger Amy B, Lorenzi Gayle M, de Boer Ian H, Perkins Bruce A, Paterson Andrew D

Abstract excerpt

KEY POINTS: Previous research has identified polygenic risk scores that are associated with low eGFR and albuminuria in the general population. We observed that these eGFR and albuminuria polygenic risk scores were associated with eGFR and albuminuria, respectively, in type 1 diabetes. Associations were independent of glycemic control and suggest shared genetic kidney risk factors between type 1 diabetes and the...

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Topics

Humans
Diabetes Mellitus, Type 1
Male
Glomerular Filtration Rate
Female
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Albuminuria

Genetic Risk Score

Diabetic Nephropathies

Risk Factors

Genetic Predisposition to Disease

Kidney

Young Adult

Collagen Type IV

Autoantigens

Source

Open in PubMed Open full text

Identifiers

PMID: 42371715
DOI: 10.2215/CJN.0000001111
PMCID: PMC13549490

Genes

COL4A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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