Article
A framework for detecting causal effects of risk factors at an individual level based on principles of Mendelian randomisation: applications to modelling individualised effects of lipids on coronary artery disease.
EBioMedicine - 1 Mar 2025
Shi Yujia, Xiang Yong, Ye Yuxin, He Tingwei, Sham Pak-Chung, So Hon-Cheong
Abstract excerpt
BACKGROUND: Mendelian Randomisation (MR) has been widely used to study the causal effects of risk factors. However, almost all MR studies concentrate on the population's average causal effects. With the advent of precision medicine, the individualised treatment effect (ITE) is often of greater interest. For instance, certain risk factors may pose a higher risk to some individuals than others, and the benefits of...
Read the complete abstract on PubMedTopics
- Humans
- Mendelian Randomization Analysis
- Coronary Artery Disease
- Polymorphism, Single Nucleotide
- Risk Factors