Article
Nucleolin in the cell membrane promotes Ang II-mediated VSMC phenotypic switching by regulating the AT1R internalization function : Nucleolin promotes Ang II-mediated VSMC phenotypic switching.
Biology direct - 26 Feb 2025
Fang Li, Shen Zhijie, Zhang Yinzhuang, Mao Zhuoni, Huang Dan, Lou Chenyu
Abstract excerpt
BACKGROUND: Nucleolin (NCL) plays an important regulatory role in angiotensin II (Ang II)-induced phenotypic switching of vascular smooth muscle cells (VSMCs). The aim of this study was to discuss its potential regulatory mechanisms. RESULTS: We investigated if the pathways involving Ang II type 1 receptor (AT1R) and PKC/MAPK are responsible for Ang II's effects on VSMC phenotypic switching. Ang II upregulated...
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