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Article

Upregulation of TRPM7 channels by angiotensin II triggers phenotypic switching of vascular smooth muscle cells of ascending aorta.

Circulation research - 12 Oct 2012

Zhang Zheng, Wang Mi, Fan Xiao-Han, Chen Jing-Hui, Guan Yong-Yuan, Tang Yong-Bo

Abstract excerpt

RATIONALE: Angiotensin II (Ang II) has pleiotropic effects on vascular smooth muscle cells (VSMCs). It has been demonstrated to promote the proliferative phenotype of VSMCs in mouse ascending aorta, but the underlying mechanisms remain incompletely understood. OBJECTIVE: The present study was designed to explore whether the Ca(2+)-permeable transient receptor potential melastatin 7 (TRPM7) channel is involved in...

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Source

Identifiers

PMID: 22896586
DOI: 10.1161/CIRCRESAHA.112.273755

Genes

TRPM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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