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Article

TRPV1 activation inhibits phenotypic switching and oxidative stress in vascular smooth muscle cells by upregulating PPARα.

Biochemical and biophysical research communications - 19 Mar 2021

Zhou Yi, Wang Xueli, Guo Lu, Chen Lizhao, Zhang Mingjie, Chen Xue, Li Jingcheng, Zhang Lili

Abstract excerpt

The proliferation and migration of vascular smooth muscle cells (VSMCs) is one of main reasons of vascular remodeling and is the pathogenesis of atherosclerosis and other vascular diseases. Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin. TRPV1 has been previously reported to inhibit proliferation, migration and phenotypic switching, but the regulatory mechanisms and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33550097
DOI: 10.1016/j.bbrc.2021.01.072

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