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Article

New insights into phenotypic switching of VSMCs induced by hyperhomocysteinemia: Role of endothelin-1 signaling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2020

Chen Yulong, Su Xingli, Qin Qiaohong, Yu Yue, Jia Min, Zhang Hongmei, Li Huijin, Pei Leilei

Abstract excerpt

Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Hyperhomocysteinemia (HHcy) is an independent risk factor for atherosclerosis. HHcy induces phenotypic switching of VSMCs, but the mechanism is unclear. Endothelin-1 (ET-1) promotes proliferation and migration of VSMCs by inducing phenotypic switching during atherosclerosis. This review examined recent findings on...

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Identifiers

PMID: 31864211
DOI: 10.1016/j.biopha.2019.109758

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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