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Article

WNK1 is required for proliferation induced by hypotonic challenge in rat vascular smooth muscle cells.

Acta pharmacologica Sinica - 1 Jan 2018

Zhang Ya-Juan, Zheng Hua-Qing, Chen Bao-Yi, Sun Lu, Ma Ming-Ming, Wang Guan-Lei, Guan Yong-Yuan

Abstract excerpt

Hypotonic challenge evoked vascular cell proliferation through activation of volume-regulated Cl- channel (VRCC), leading to a decrease in the intracellular Cl- concentration ([Cl-]i). We hypothesize that the decrease in [Cl-]i may activate one or several Cl--sensitive kinases, resulting in a subsequent signaling cascade. In this study we demonstrated that WNK1, a Cl--sensitive kinase, was involved in...

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Source

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Identifiers

PMID: 28770829
DOI: 10.1038/aps.2017.56
PMCID: PMC5758668

Genes

WNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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