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Article

Serum amyloid A drive microglia shift to a resolving phenotype through Nrf2.

Neuropharmacology - 1 Jun 2025

Li Qi, Huang Yiwei, Ban Tao, Chen Kexin, Zhen Xuechu, Dai Qijun, Zhang Gufang

Abstract excerpt

Serum amyloid A (SAA) is an acute-phase protein that has been recognized as a diagnostic biomarker for several diseases. However, the functional studies about the effects of SAA on microglial activation seem controversial. Here, we discovered that SAA induces microglial cells polarize to a pro-resolving M2 phenotype by promoting the stability of the transcription factor Nrf2, which specifically regulates...

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PMID: 39983914
DOI: 10.1016/j.neuropharm.2025.110374

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