Article

Long-term Nrf2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy

2025-06-15

Abstract excerpt

<h4>ABSTRACT</h4> A prominent pathological feature of tauopathies, including Alzheimer’s disease, is a chronic microglial reactivity, which contributes to neuroinflammation and disease progression. Microglia, the innate immune cells of the brain, can be pharmacologically eliminated by inhibiting the colony stimulating factor 1 receptor (e.g. with PLX5622), which is essential for their survival and proliferation....

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Literature Corpus work: 900276d8-1c1c-5be3-a2f8-bd8734d59508
DOI: 10.1101/2025.06.11.659019

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