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Article

Experimental evolution reveals adaptive pathways to reduced antibiotic susceptibility in Pseudomonas aeruginosa biofilms.

Microbiology (Reading, England) - 1 May 2026

Vergauwe Fauve, Sass Andrea, Madduri Abhinav, Van Nieuwerburgh Filip, Coenye Tom

Abstract excerpt

In the present study, we used an experimental evolution approach to investigate how reduced antibiotic susceptibility develops in biofilms formed by Pseudomonas aeruginosa when they are exposed to the clinically relevant antibiotics tobramycin and meropenem. Two biofilm model systems were used, one mimicking surface-attached biofilms (multiple independent P. aeruginosa lineages originating from P. aeruginosa...

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Identifiers

PMID: 42207565
DOI: 10.1099/mic.0.001715
PMCID: PMC13218686

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