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Article

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.

mBio - 31 Oct 2017

Jorth Peter, McLean Kathryn, Ratjen Anina, Secor Patrick R, Bautista Gilbert E, Ravishankar Sumedha, Rezayat Amir, Garudathri Jayanthi, Harrison Joe J, Harwood Rachel A, Penewit Kelsi, Waalkes Adam, Singh Pradeep K, Salipante Stephen J

Abstract excerpt

While much attention has been focused on acquired antibiotic resistance genes, chromosomal mutations may be most important in chronic infections where isolated, persistently infecting lineages experience repeated antibiotic exposure. Here, we used experimental evolution and whole-genome sequencing to investigate chromosomally encoded mutations causing aztreonam resistance in Pseudomonas aeruginosa and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29089424
DOI: 10.1128/mBio.00517-17
PMCID: PMC5666152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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