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Article

Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.

PloS one - 1 Jan 2011

Jain Roshan A, Wolman Marc A, Schmidt Lauren A, Burgess Harold A, Granato Michael

Abstract excerpt

Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitive zebrafish houdini...

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Identifiers

PMID: 22039502
DOI: 10.1371/journal.pone.0026510
PMCID: PMC3198425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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