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SGK1 drives hippocampal demyelination and diabetes-associated cognitive dysfunction in mice

17 Feb 2025

Abstract excerpt

Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. The complex pathology of DACD remains unknown. Here, we performed single-nucleus RNA sequencing (snRNA-seq) to demonstrate unique cellular and molecular patterns of the hippocampus from a mouse model of diabetes. More in-depth analysis of oligodendrocytes (OLs) distinguished five subclusters,...

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PMID: 39962079
DOI: 10.1038/s41467-025-56854-2

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