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The histone chaperone Spn1 preserves chromatin protections at promoters and nucleosome positioning in open reading frames.

G3 (Bethesda, Md.) - 17 Apr 2025

Tonsager Andrew J, Zukowski Alexis, Radebaugh Catherine A, Weirich Abigail, Stargell Laurie A, Ramachandran Srinivas

Abstract excerpt

Spn1 is a multifunctional histone chaperone that associates with RNA polymerase II during elongation and is essential for life in eukaryotes. While previous work has elucidated regions of the protein important for its many interactions, it is unknown how these domains contribute to the maintenance of chromatin structure. Here, we employ digestion by micrococcal nuclease followed by single-stranded library...

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Share to Chromatin
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39960479
DOI: 10.1093/g3journal/jkaf032
PMCID: PMC12005155

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