Article
Chromatin remodelers clear nucleosomes from intrinsically unfavorable sites to establish nucleosome-depleted regions at promoters.
Molecular biology of the cell - 15 Jun 2011
Tolkunov Denis, Zawadzki Karl A, Singer Cara, Elfving Nils, Morozov Alexandre V, Broach James R
Abstract excerpt
Most promoters in yeast contain a nucleosome-depleted region (NDR), but the mechanisms by which NDRs are established and maintained in vivo are currently unclear. We have examined how genome-wide nucleosome placement is altered in the absence of two distinct types of nucleosome remodeling activity. In mutants of both SNF2, which encodes the ATPase component of the Swi/Snf remodeling complex, and ASF1, which...
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