Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma.

doi:10.1186/s13046-025-03289-8

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Article

Suppression of Spry1 reduces HIF1α-dependent glycolysis and impairs angiogenesis in BRAF-mutant cutaneous melanoma.

Journal of experimental & clinical cancer research : CR - 14 Feb 2025

Montico Barbara, Giurato Giorgio, Guerrieri Roberto, Colizzi Francesca, Salvati Annamaria, Nassa Giovanni, Lamberti Jessica, Memoli Domenico, Sabatelli Patrizia, Comelli Marina, Bellazzo Arianna, Fejza Albina, Camicia Lucrezia, Baboci Lorena, Dal Bo Michele, Covre Alessia, Nyman Tuula A, Weisz Alessandro, Steffan Agostino, Maio Michele, Sigalotti Luca, Mongiat Maurizio, Andreuzzi Eva, Fratta Elisabetta

Abstract excerpt

BACKGROUND: About 50% of cutaneous melanoma (CM) harbors the activating BRAFV600 mutation which exerts most of the oncogenic effects through the MAPK signaling pathway. In the last years, a number of MAPK modulators have been identified, including Spry1. In this context, we have recently demonstrated that knockout of Spry1 (Spry1KO) in BRAFV600-mutant CM led to cell cycle arrest and apoptosis, repressed cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypoxia-Inducible Factor 1, alpha Subunit

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Identifiers

PMID: 39953610
DOI: 10.1186/s13046-025-03289-8
PMCID: PMC11827140

Genes

BRAF

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