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Article

Simvastatin reprograms lipid metabolism in B16.F10 melanoma cells to favor an early resistant phenotype.

Scientific reports - 21 May 2026

Negrea Giorgiana-Gabriela, Balacescu Loredana, Pavel Ilie Ovidiu, Sesarman Alina, Banciu Manuela

Abstract excerpt

Our previous studies demonstrated that simvastatin (SIM) inhibited B16.F10 murine melanoma cell proliferation in vivo and in vitro via strong suppressing the production of subunit α of hypoxia inducible factor 1 (HIF-1) (HIF-1 α)-a key regulator of cancer cell adaptation to hypoxia. However, beyond its known role in hypoxia, normoxic expression of HIF-1α in melanoma has been linked to increased cancer cell...

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Share to Citric Acid Cycle
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Glucose

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Lipid Metabolism

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Source

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Identifiers

PMID: 42168432
DOI: 10.1038/s41598-026-52873-1
PMCID: PMC13396812

Genes

F10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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