Article
The RhoJ-BAD signaling network: An Achilles' heel for BRAF mutant melanomas.
PLoS genetics - 1 Jul 2017
Ruiz Rolando, Jahid Sohail, Harris Melissa, Marzese Diego M, Espitia Francisco, Vasudeva Priya, Chen Chi-Fen, de Feraudy Sebastien, Wu Jie, Gillen Daniel L, Krasieva Tatiana B, Tromberg Bruce J, Pavan William J, Hoon Dave S, Ganesan Anand K
Abstract excerpt
Genes and pathways that allow cells to cope with oncogene-induced stress represent selective cancer therapeutic targets that remain largely undiscovered. In this study, we identify a RhoJ signaling pathway that is a selective therapeutic target for BRAF mutant cells. RhoJ deletion in BRAF mutant melanocytes modulates the expression of the pro-apoptotic protein BAD as well as genes involved in cellular metabolism,...
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