Article
Oncogenic BRAF regulates oxidative metabolism via PGC1α and MITF.
Cancer cell - 18 Mar 2013
Haq Rizwan, Shoag Jonathan, Andreu-Perez Pedro, Yokoyama Satoru, Edelman Hannah, Rowe Glenn C, Frederick Dennie T, Hurley Aeron D, Nellore Abhinav, Kung Andrew L, Wargo Jennifer A, Song Jun S, Fisher David E, Arany Zolt, Widlund Hans R
Abstract excerpt
Activating mutations in BRAF are the most common genetic alterations in melanoma. Inhibition of BRAF by small molecules leads to cell-cycle arrest and apoptosis. We show here that BRAF inhibition also induces an oxidative phosphorylation gene program, mitochondrial biogenesis, and the increased expression of the mitochondrial master regulator, PGC1α. We further show that a target of BRAF, the melanocyte lineage...
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