Article
Molecular identification of a renal urate anion exchanger that regulates blood urate levels.
Nature - 23 May 2002
Enomoto Atsushi, Kimura Hiroaki, Chairoungdua Arthit, Shigeta Yasuhiro, Jutabha Promsuk, Cha Seok Ho, Hosoyamada Makoto, Takeda Michio, Sekine Takashi, Igarashi Takashi, Matsuo Hirotaka, Kikuchi Yuichi, Oda Takashi, Ichida Kimiyoshi, Hosoya Tatsuo, Shimokata Kaoru, Niwa Toshimitsu, Kanai Yoshikatsu, Endou Hitoshi
Abstract excerpt
Urate, a naturally occurring product of purine metabolism, is a scavenger of biological oxidants implicated in numerous disease processes, as demonstrated by its capacity of neuroprotection. It is present at higher levels in human blood (200 500 microM) than in other mammals, because humans have an effective renal urate reabsorption system, despite their evolutionary loss of hepatic uricase by mutational...
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