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Causal Relationship between Inflammatory Proteins and Alzheimer's Disease: A Two-Sample Bidirectional Mendelian Randomization Study.

Dementia and geriatric cognitive disorders - 1 Jan 2026

Xu Rui, Gao Yongjun

Abstract excerpt

INTRODUCTION: Studies on Alzheimer's disease (AD) indicate inflammation does not just follow but drives neurodegeneration. Protein aggregation in neurodegeneration can trigger neuroinflammation, worsening protein aggregation and neurodegeneration. The aim of this study was to use bidirectional Mendelian randomization (MR) approach to find the causal link between specific inflammatory proteins and AD, creating new...

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PMID: 40532678
DOI: 10.1159/000546762

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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