Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens.

doi:10.1093/infdis/jiaf539

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Article

Extreme Genetic Diversity and Signatures of Balancing Selection in Plasmodium vivax Blood-Stage Antigens.

The Journal of infectious diseases - 17 Mar 2026

Bareng Alison Paolo N, Naung Myo T, Martin Eli, Mehra Somya, Munro Jacob E, Takala Harrison Shannon, Barry Alyssa E

Abstract excerpt

BACKGROUND: Knowledge of the genetic diversity of Plasmodium vivax antigen vaccine candidates can offer valuable insights into antigens targeted by host immunity and their utility as vaccine candidates. We previously catalogued the genetic diversity of DBP, MSP1, and members of the RBP family. Here we report the diversity of 14 additional P vivax vaccine candidates to identify polymorphic domains and immune...

Topics

Plasmodium vivax
Antigens, Protozoan
Genetic Variation
Selection, Genetic
Malaria, Vivax
Protozoan Proteins
Humans
Malaria Vaccines
Asia

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PMID: 41128014
DOI: 10.1093/infdis/jiaf539
PMCID: PMC13017313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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