Article
Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 2003
Doolan Denise L, Southwood Scott, Freilich Daniel A, Sidney John, Graber Norma L, Shatney Lori, Bebris Lolita, Florens Laurence, Dobano Carlota, Witney Adam A, Appella Ettore, Hoffman Stephen L, Yates John R, Carucci Daniel J, Sette Alessandro
Abstract excerpt
The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in the context of Plasmodium falciparum, a strategy that rapidly identifies target antigens from large and complex genomes. Sixteen antigenic proteins recognized by volunteers immunized with radiation-attenuated P....
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