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Article

Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.

Frontiers in immunology - 1 Jan 2018

Wentink Marjolein W J, Mueller Yvonne M, Dalm Virgil A S H, Driessen Gertjan J, van Hagen P Martin, van Montfrans Joris M, van der Burg Mirjam, Katsikis Peter D

Abstract excerpt

Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral immunodeficiency, lymphadenopathy, and an inability to control persistent viral infections including Epstein-Barr virus (EBV) and cytomegalovirus (CMV) infections. Understanding the mechanisms leading to impaired immune response is important...

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Identifiers

PMID: 29563914
DOI: 10.3389/fimmu.2018.00446
PMCID: PMC5845988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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