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Article

Genetic Defects in Phosphoinositide 3-Kinase δ Influence CD8+ T Cell Survival, Differentiation, and Function.

Frontiers in immunology - 1 Jan 2018

Cannons Jennifer L, Preite Silvia, Kapnick Senta M, Uzel Gulbu, Schwartzberg Pamela L

Abstract excerpt

Activated phosphoinositide 3-kinase delta syndrome (APDS), also known as p110 delta-activating mutation causing senescent T cells, lymphadenopathy and immunodeficiency (PASLI), is an autosomal dominant primary human immunodeficiency (PID) caused by heterozygous gain-of-function mutations in PIK3CD, which encodes the p110δ catalytic subunit of PI3K. This recently described PID is characterized by diverse and...

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Identifiers

PMID: 30116245
DOI: 10.3389/fimmu.2018.01758
PMCID: PMC6082933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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