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Article

The Role of PD-1 in Acute and Chronic Infection.

Frontiers in immunology - 1 Jan 2020

Jubel Jil M, Barbati Zachary R, Burger Christof, Wirtz Dieter C, Schildberg Frank A

Abstract excerpt

PD-1 as an immune checkpoint molecule down-regulates T cell activity during immune responses in order to prevent autoimmune tissue damage. In chronic infections or tumors, lasting antigen-exposure leads to permanent PD-1 expression that can limit immune-mediated clearance of pathogens or degenerated cells. Blocking PD-1 can enhance T cell function; in cancer treatment PD-1 blockade is already used as a successful...

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Identifiers

PMID: 32265932
DOI: 10.3389/fimmu.2020.00487
PMCID: PMC7105608

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