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Article

Coinhibitory receptors and CD8 T cell exhaustion in chronic infections

10 Jul 2014

Abstract excerpt

PURPOSE OF REVIEW: To describe the recent data on the role of coinhibitory receptors, such as PD-1, Tim-3, CD160, as mediators of the 'exhaustion' of virus-specific CD8 T cells in chronic infections and particularly in HIV. RECENT FINDINGS: Exhaustion of chronic virus-specific CD8 T cells is a dynamic process characterized by altered differentiation, impaired function, and compromised proliferation/survival...

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Identifiers

PMID: 25010894
DOI: 10.1097/coh.0000000000000088

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