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Article

Deubiquitinase USP9X controls Wnt signaling for CNS vascular formation and barrier maintenance

4 Feb 2025

Abstract excerpt

Deubiquitinating enzymes play crucial roles in various cellular activities, yet their involvement in central nervous system (CNS) vascularization and barrier function remains elusive. Canonical Wnt signaling is essential for proper CNS vascularization and barrier maintenance. Using a loss-of-function screening for Wnt-signaling activity, we identified ubiquitin-specific peptidase 9 X-linked (USP9X) as a key...

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PMID: 39909046
DOI: 10.1016/j.devcel.2025.01.009

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