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Article

Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity.

Nature communications - 17 Sept 2024

Bassi Ivan, Grunspan Moshe, Hen Gideon, Ravichandran Kishore A, Moshe Noga, Gutierrez-Miranda Laura, Safriel Stav R, Kostina Daria, Shen Amitay, Ruiz de Almodovar Carmen, Yaniv Karina

Abstract excerpt

The neurovascular unit (NVU) is a complex multicellular structure that helps maintain cerebral homeostasis and blood-brain barrier (BBB) integrity. While extensive evidence links NVU alterations to cerebrovascular diseases and neurodegeneration, the underlying molecular mechanisms remain unclear. Here, we use zebrafish embryos carrying a mutation in Scavenger Receptor B2, a highly conserved endolysosomal protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39289367
DOI: 10.1038/s41467-024-52365-8
PMCID: PMC11408700

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