Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.

Molecular cell - 5 Aug 2021

Fu Yesheng, Wang Hongtian, Dai Hongmiao, Zhu Qiong, Cui Chun-Ping, Sun Xiaoxuan, Li Yanchang, Deng Zhikang, Zhou Xuemei, Ge Yingwei, Peng Zhiqiang, Yuan Chao, Wu Bo, Yang Xi, Li Rongyu, Liu Cui Hua, He Fuchu, Wei Wenyi, Zhang Lingqiang

Abstract excerpt

OTULIN coordinates with LUBAC to edit linear polyubiquitin chains in embryonic development, autoimmunity, and inflammatory diseases. However, the mechanism by which angiogenesis, especially that of endothelial cells (ECs), is regulated by linear ubiquitination remains unclear. Here, we reveal that constitutive or EC-specific deletion of Otulin resulted in arteriovenous malformations and embryonic lethality. LUBAC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activin Receptors, Type II
Share to Human Umbilical Vein Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiprotein Complexes

Share to Neovascularization, Pathologic

Share to Neovascularization, Physiologic

Share to Polyubiquitin

Share to Smad1 Protein

Share to Telangiectasia, Hereditary Hemorrhagic

Source

Identifiers

PMID: 34157307
DOI: 10.1016/j.molcel.2021.05.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin.PMID 34157307Read ↗

The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.Semantic proximity Read ↗

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and AutoimmunitySemantic proximity Read ↗

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked PolyubiquitinSemantic proximity Read ↗

A Key Cytoskeletal Regulator of Ubiquitination Amplifies TGFβ Signaling During Mouse Developmental Vascular PatterningSemantic proximity Read ↗

Functional divergence of WWC family proteins in human endothelial cellsSemantic proximity Read ↗

Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.Semantic proximity Read ↗

A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome.Semantic proximity Read ↗

YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.Semantic proximity Read ↗

ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2Semantic proximity Read ↗

ALK1 signaling regulates early postnatal lymphatic vessel developmentSemantic proximity Read ↗

Canonical Wnt induction by OTULIN prevents keratinocyte death and skin inflammationSemantic proximity Read ↗

Overexpression of Activin Receptor-Like Kinase 1 in Endothelial Cells Suppresses Development of Arteriovenous Malformations in Mouse Models of Hereditary Hemorrhagic Telangiectasia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.