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Article

Tbx1 regulates brain vascularization.

Human molecular genetics - 1 Jan 2014

Cioffi Sara, Martucciello Stefania, Fulcoli Filomena Gabriella, Bilio Marchesa, Ferrentino Rosa, Nusco Edoardo, Illingworth Elizabeth

Abstract excerpt

The transcription factor TBX1 is the major gene involved in 22q11.2 deletion syndrome (22q11.2DS). Using mouse models of these diseases, we have previously shown that TBX1 activates VEGFR3 in endothelial cells (EC), and that this interaction is critical for the development of the lymphatic vascul...

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Share to Neovascularization, Pathologic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

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Share to Gene Knockdown Techniques

Share to Human Umbilical Vein Endothelial Cells

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Source

Identifiers

PMID: 23945394
DOI: 10.1093/hmg/ddt400

Genes

TBX1
DLL4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23945394-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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