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Article

The vascular endothelial cell-expressed prion protein Prnd/Doppel promotes angiogenesis and blood-brain barrier development

1 Jan 2020

Abstract excerpt

The central nervous system (CNS) contains a complex network of blood vessels that promote normal tissue development and physiology. Abnormal control of blood vessel morphogenesis and maturation is linked to the pathogenesis of various neurodevelopmental diseases. The CNS-specific genes that regulate blood vessel morphogenesis in development and disease remain largely unknown. Here, we have characterized functions...

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Share to Barrier Structure and Function Studies
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PMID: 32895288
DOI: 10.1242/dev.193094

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