Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

doi:10.1001/jama.296.6.661

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Article

Collaborative analysis of alpha-synuclein gene promoter variability and Parkinson disease.

JAMA - 9 Aug 2006

Maraganore Demetrius M, de Andrade Mariza, Elbaz Alexis, Farrer Matthew J, Ioannidis John P, Krüger Rejko, Rocca Walter A, Schneider Nicole K, Lesnick Timothy G, Lincoln Sarah J, Hulihan Mary M, Aasly Jan O, Ashizawa Tetsuo, Chartier-Harlin Marie-Christine, Checkoway Harvey, Ferrarese Carlo, Hadjigeorgiou Georgios, Hattori Nobutaka, Kawakami Hideshi, Lambert Jean-Charles, Lynch Timothy, Mellick George D, Papapetropoulos Spiridon, Parsian Abbas, Quattrone Aldo, Riess Olaf, Tan Eng-King, Van Broeckhoven Christine

Abstract excerpt

CONTEXT: Identification and replication of susceptibility genes for Parkinson disease at the population level have been hampered by small studies with potential biases. Alpha-synuclein (SNCA) has been one of the most promising susceptibility genes, but large-scale studies have been lacking. OBJECTIVE: To determine whether allele-length variability in the dinucleotide repeat sequence (REP1) of the SNCA gene...

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PMID: 16896109
DOI: 10.1001/jama.296.6.661

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SNCA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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