Article
SNCA-Rep1 polymorphism correlates with susceptibility and iron deficiency in restless legs syndrome.
Parkinsonism & related disorders - 1 Dec 2020
Zhu Xiao-Ying, Wang Hong-Ming, Wu Ting-Ting, Liu Te, Chen Ya-Jing, Li Xuan, Chen Tian-Jiao, Liu Ye, Zhang Xiao-Jin, Wang Xi-Xi, Zhang Yue, Ondo William G, Wu Yun-Cheng
Abstract excerpt
BACKGROUND: Brain iron disequilibrium and dopaminergic dysfunction are key pathophysiological features of Restless Legs Syndrome (RLS). Rep1 polymorphism in the promotor region of SNCA is associated with risk of Parkinson's disease, however its association with RLS and iron status is unclear. OBJECTIVE: To investigate SNCA-Rep1 polymorphism in RLS and its phenotypes. METHODS: We recruited RLS patients as well as...
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