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Article

Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation.

Open biology - 1 Feb 2025

Nagy Agota, Kovacs Levente, Rangone Helene, Fu Jingyan, Ladinsky Mark, Glover David M

Abstract excerpt

The conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4's phosphorylation of Ana1/STIL. Subsequently, the centriole undergoes conversion to a centrosome requiring its radial expansion and elongation, mediated by a network requiring interactions between Cep135, Ana1/Cep295 and Asterless/Cep152. Here, we show that mutant alleles encoding overlapping N-...

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Identifiers

PMID: 39904373
DOI: 10.1098/rsob.240325
PMCID: PMC11793955

Genes

STIL

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