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Article

An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly.

The Journal of cell biology - 2 Apr 2018

McLamarrah Tiffany A, Buster Daniel W, Galletta Brian J, Boese Cody J, Ryniawec John M, Hollingsworth Natalie Ann, Byrnes Amy E, Brownlee Christopher W, Slep Kevin C, Rusan Nasser M, Rogers Gregory C

Abstract excerpt

Polo-like kinase 4 (Plk4) initiates an early step in centriole assembly by phosphorylating Ana2/STIL, a structural component of the procentriole. Here, we show that Plk4 binding to the central coiled-coil (CC) of Ana2 is a conserved event involving Polo-box 3 and a previously unidentified putative CC located adjacent to the kinase domain. Ana2 is then phosphorylated along its length. Previous studies showed that...

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Identifiers

PMID: 29496738
DOI: 10.1083/jcb.201605106
PMCID: PMC5881488

Genes

STIL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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