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Article

Cross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways.

Rheumatology (Oxford, England) - 1 Jun 2025

Rosa-Baez Carlos, Borrego-Yaniz Gonzalo, Rodriguez-Martin Inmaculada, Kerick Martin, Acosta-Herrera Marialbert, Martín Javier, Ortiz-Fernández Lourdes

Abstract excerpt

OBJECTIVES: Coronavirus disease 2019 (COVID-19) and SSc share multiple similarities in their clinical manifestations, alterations in immune response and therapeutic options. These resemblances have also been identified in other immune-mediated inflammatory diseases where a common genetic component has been found. Thus, we decided to evaluate for the first time this shared genetic architecture with SSc. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to PPAR gamma

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Share to Scleroderma, Systemic

Source

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Identifiers

PMID: 39878951
DOI: 10.1093/rheumatology/keaf028
PMCID: PMC12107044

Genes

BMP1
PPARG
SENP7
TYK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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