Article
Novel pleiotropic loci link vascular and immune pathways in systemic sclerosis and primary Raynaud's phenomenon.
Rheumatology (Oxford, England) - 5 May 2026
Rangel-Peláez Carlos, Rodriguez-Martin Inmaculada, Rosa-Baez Carlos, Kerick Martin, Guillén-Del-Castillo Alfredo, Simeón-Aznar Carmen P, Callejas José L, Distler Oliver, Proudman Susanna M, Nikpour Mandana, Hunzelmann Nicolas, Moroncini Gianluca, de Vries-Bouwstra Jeska K, Herrick Ariane L, Allanore Yannick, Alarcón-Riquelme Marta E, Beretta Lorenzo, Mayes Maureen D, Denton Christopher P, Assassi Shervin, Martín Javier, Acosta-Herrera Marialbert, Ortiz-Fernández Lourdes
Abstract excerpt
OBJECTIVE: Raynaud's phenomenon (RP) is the first noticeable symptom of systemic sclerosis (SSc), appearing even years before other signs. Vascular and immune pathways, hallmarks in SSc pathogenesis, are implicated in primary RP. Hence, we aimed to define the shared genetic architecture between these conditions to explore pathogenic mechanisms and whether pleiotropic loci could help identify primary RP patients...
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