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Article

Strength of Genetic Associations with Thyrotropin Values Differs Between Populations with Similarity to African and European Reference Populations.

Thyroid : official journal of the American Thyroid Association - 1 Feb 2025

Wade Alisha N, Guare Lindsay, Hayat Mahtaab, Straub Peter, Gao Ziyue, Medici Marco, Teumer Alexander, Davis Lea K, Ramsay Michèle, Ritchie Marylyn D, BioBank Penn Medicine, Cappola Anne R

Abstract excerpt

Background: Epidemiological data suggest the population distribution of thyrotropin (TSH) values is shifted toward lower values in self-identified Black non-Hispanic individuals compared with self-identified White non-Hispanic individuals. It is unknown whether genetic differences between individuals with genetic similarities to African reference populations (GSA) and those with similarities to European reference...

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3',5'-Cyclic-AMP Phosphodiesterases
Black or African American
Black People
Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 39869013
DOI: 10.1089/thy.2024.0525

Genes

PDE8B
PDE10A
NFIA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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