Article
A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels.
European journal of endocrinology - 1 May 2011
Medici Marco, van der Deure Wendy M, Verbiest Michael, Vermeulen Sita H, Hansen Pia S, Kiemeney Lambertus A, Hermus Ad R M M, Breteler Monique M, Hofman Albert, Hegedüs Laszlo, Kyvik Kirsten Ohm, den Heijer Martin, Uitterlinden André G, Visser Theo J, Peeters Robin P
Abstract excerpt
OBJECTIVE: Minor variation in serum thyroid hormone (TH) levels can have important effects on various clinical endpoints. Although 45-65% of the inter-individual variation in serum TH levels is due to genetic factors, the causative genes are not well established. We therefore studied the effects of genetic variation in 68 TH pathway genes on serum TSH and free thyroxine (FT(4)) levels. DESIGN AND METHODS:...
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