Article
Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
PloS one - 1 Jan 2014
Malinowski Jennifer R, Denny Joshua C, Bielinski Suzette J, Basford Melissa A, Bradford Yuki, Peissig Peggy L, Carrell David, Crosslin David R, Pathak Jyotishman, Rasmussen Luke, Pacheco Jennifer, Kho Abel, Newton Katherine M, Li Rongling, Kullo Iftikhar J, Chute Christopher G, Chisholm Rex L, Jarvik Gail P, Larson Eric B, McCarty Catherine A, Masys Daniel R, Roden Dan M, de Andrade Mariza, Ritchie Marylyn D, Crawford Dana C
Abstract excerpt
Thyroid stimulating hormone (TSH) hormone levels are normally tightly regulated within an individual; thus, relatively small variations may indicate thyroid disease. Genome-wide association studies (GWAS) have identified variants in PDE8B and FOXE1 that are associated with TSH levels. However, prior studies lacked racial/ethnic diversity, limiting the generalization of these findings to individuals of...
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