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Article

Phenotype of POLE-mutated endometrial cancer

27 Mar 2019

Abstract excerpt

BACKGROUND AND PURPOSE: Individualized therapy in endometrial cancer, the most common gynaecologic cancer in the developed world, focuses on identifying specific molecular subtypes. Mutations in the exonuclease domain of the DNA polymerase epsilon (POLE) gene define one such subtype, which causes an ultra-mutated tumour phenotype. These tumours may have an improved progression-free survival and may be receptive...

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Share to Endometrial and Cervical Cancer Treatments
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PMID: 30917185
DOI: 10.1371/journal.pone.0214318

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