Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae.

Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 2020

Carballar-Lejarazú Rebeca, Ogaugwu Christian, Tushar Taylor, Kelsey Adam, Pham Thai Binh, Murphy Jazmin, Schmidt Hanno, Lee Yoosook, Lanzaro Gregory C, James Anthony A

Abstract excerpt

A Cas9/guide RNA-based gene drive strain, AgNosCd-1, was developed to deliver antiparasite effector molecules to the malaria vector mosquito, Anopheles gambiae The drive system targets the cardinal gene ortholog producing a red-eye phenotype. Drive can achieve 98 to 100% in both sexes and full introduction was observed in small cage trials within 6 to 10 generations following a single release of gene-drive males....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Anopheles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Cas Systems

Share to High-Throughput Nucleotide Sequencing

Share to Malaria

Share to Mosquito Control

Share to Mosquito Vectors

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 32839345
DOI: 10.1073/pnas.2010214117
PMCID: PMC7502704

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae.PMID 32839345Read ↗

Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgroundsSemantic proximity Read ↗

Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.Semantic proximity Read ↗

A confined gene drive for population modification in the malaria vector <i>Anopheles stephensi</i>Semantic proximity Read ↗

Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae.Semantic proximity Read ↗

Cas9-mediated maternal effect and derived resistance alleles in a gene-drive strain of the African malaria vector mosquito, Anopheles gambiae.Semantic proximity Read ↗

Gene drives: an alternative approach to malaria control?Semantic proximity Read ↗

Gene drive-based population suppression in the malaria vector Anopheles stephensiSemantic proximity Read ↗

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes.Semantic proximity Read ↗

Gene drive-based population suppression in the malaria vector <i>Anopheles stephensi</i>Semantic proximity Read ↗

Mutant allele formation and inheritance during Cas9/guide RNA-mediated gene drive in a population modification mosquito strain for human malaria control.Semantic proximity Read ↗

Dual effector population modification gene-drive strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzziiSemantic proximity Read ↗

Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.