Article
The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.
Cell - 26 Jul 2018
Willsey A Jeremy, Morris Montana T, Wang Sheng, Willsey Helen R, Sun Nawei, Teerikorpi Nia, Baum Tierney B, Cagney Gerard, Bender Kevin J, Desai Tejal A, Srivastava Deepak, Davis Graeme W, Doudna Jennifer, Chang Edward, Sohal Vikaas, Lowenstein Daniel H, Li Hao, Agard David, Keiser Michael J, Shoichet Brian, von Zastrow Mark, Mucke Lennart, Finkbeiner Steven, Gan Li, Sestan Nenad, Ward Michael E, Huttenhain Ruth, Nowakowski Tomasz J, Bellen Hugo J, Frank Loren M, Khokha Mustafa K, Lifton Richard P, Kampmann Martin, Ideker Trey, State Matthew W, Krogan Nevan J
Abstract excerpt
Although gene discovery in neuropsychiatric disorders, including autism spectrum disorder, intellectual disability, epilepsy, schizophrenia, and Tourette disorder, has accelerated, resulting in a large number of molecular clues, it has proven difficult to generate specific hypotheses without the corresponding datasets at the protein complex and functional pathway level. Here, we describe one path forward-an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.