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Article

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap.

Science (New York, N.Y.) - 9 Feb 2018

Gandal Michael J, Haney Jillian R, Parikshak Neelroop N, Leppa Virpi, Ramaswami Gokul, Hartl Chris, Schork Andrew J, Appadurai Vivek, Buil Alfonso, Werge Thomas M, Liu Chunyu, White Kevin P, Horvath Steve, Geschwind Daniel H

Abstract excerpt

The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29439242
DOI: 10.1126/science.aad6469
PMCID: PMC5898828

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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