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Identification of Novel Therapeutic Targets for Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2025

Zheng Zhiwei, Chen Rumeng, Liu Menghua, Ding Yining, Xu Shuling, Hou Chunyan, Li Sen

Abstract excerpt

BACKGROUND: Persistently high blood pressure remains the leading risk factor for mortality worldwide. This study aims to identify potential drug targets for hypertension. METHODS: Mendelian randomization was used to identify therapeutic targets for hypertension. Genome-wide association study summary statistics were obtained from the UK Biobank and FinnGen study. Cis-expression quantitative trait loci from the...

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Identifiers

PMID: 40109242
DOI: 10.1161/HYPERTENSIONAHA.124.24277

Genes

ACE
SLC22A4
AIMP1
CDC25A
EHMT2
FES
GPX1
GRK4
HSD3B7
NEK4
PTPN12
SIK2
SLC2A4
TNFSF12

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