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Article

Causal association between mitochondrial function and psychiatric disorders: Insights from a bidirectional two-sample Mendelian randomization study.

Journal of affective disorders - 1 Jan 2025

Lin Yun-Lu, Yao Tao, Wang Ying-Wei, Lu Jia-Hao, Chen Yan-Min, Wu Yu-Qing, Qian Xin-Ge, Liu Jing-Chen, Fang Luo-Xiang, Zheng Cheng, Wu Chun-Hui, Lin Jia-Feng

Abstract excerpt

BACKGROUND: Previous observational studies have suggested that there appears to be a close association between mitochondrial function and psychiatric disorders, but whether a causal role exists remains unclear. METHODS: We extracted genetic instruments for 67 mitochondrial-related proteins and 10 psychiatric disorders from publicly available genome-wide association studies, and employed five distinct MR methods...

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Identifiers

PMID: 39265869
DOI: 10.1016/j.jad.2024.09.039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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