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Article

Prioritizing Parkinson's disease risk-associated mitochondrial candidate genes via multi-omics integrative analysis.

Clinical neurology and neurosurgery - 1 Dec 2026

Zhu Yusheng, Ye Zihan

Abstract excerpt

BACKGROUND: Mitochondrial dysfunction has been implicated in Parkinson's disease (PD), but the genetically regulated mitochondrial genes associated with PD risk remain incompletely defined. METHODS: We conducted a summary-data-based genetic epidemiology study integrating summary-based Mendelian randomization (SMR), Heterogeneity in dependent instruments (HEIDI) filtering, and Bayesian colocalization to prioritize...

Read the complete abstract on PubMed

Topics

Humans
Parkinson Disease
Quantitative Trait Loci
Genome-Wide Association Study
Genetic Predisposition to Disease
Multiomics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Genes, Mitochondrial

DNA Methylation

Mitochondria

Source

Identifiers

PMID: 42580030
DOI: 10.1016/j.clineuro.2026.109609

Genes

MALSU1

Provenance

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